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[DOI] [PMC free article] [PubMed] [Google Scholar] 221.Mathew A.R., Di Matteo G., La Rosa P., Barbati S.A., Mannina L., Moreno S., Tata A.M., Cavallucci V., Fidaleo M
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By inhibiting the excessive activation of N-methyl-D-aspartate receptor (NMDAR), binding to calmodulin, and regulating calcium-dependent kinases such as Ca 2+ /calmodulin-dependent protein kinase II (CaMKII) and PKC, melatonin prevents excitotoxicity and activation of calcium-dependent caspases